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Bona fide PRRs with signaling capacities that reprogram gene expression include Toll-like. The C-type lectin dectin-1 binds to yeast and signals through the kinase Syk and the adaptor CARD9 to induce production of interleukin 10 (IL-10) and IL-2 in dendritic cells (DCs). Interferon regulatory factor 4 (IRF4, also known as MUM1) is a transcriptional regulator involved in several stages of immune cell development []. Synology DiskStation DS418play NAS Plex Media Server.